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When benzodiazepines and opioids are blended, the opportunity for benzodiazepines to appreciably worsen opioid-relevant respiratory despair exists. Limit dosage and duration of concomitant use of benzodiazepines and opioids, and keep an eye on individuals intently for respiratory melancholy and sedation.
The ongoing usage of benzodiazepines, like diazepam, could bring about clinically considerable physical dependence. The risks of dependence and withdrawal enhance with extended remedy length and better day-to-day dose. Abrupt discontinuation or speedy dosage reduction of diazepam after ongoing use may precipitate acute withdrawal reactions, which can be lifetime-threatening.
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Sufferers handled with flumazenil should be monitored for resedation, respiratory depression and also other residual benzodiazepine results for an proper interval right after remedy. The prescriber should pay attention to a hazard of seizure in Affiliation with flumazenil cure, particularly in lengthy-term benzodiazepine people As well as in cyclic antidepressant overdose. Caution need to be observed in the use of flumazenil in epileptic individuals treated with benzodiazepines. The entire flumazenil package insert, such as CONTRAINDICATIONS, WARNINGS, and PRECAUTIONS, needs to be consulted before use.